Publications by authors named "A Fouque"
Objectives: This study aimed to evaluate the role of alpha- and delta-cell signals on beta-cells within pancreatic mouse islets. Specifically, we investigated how these signals regulate glucose sensitivity, gene expression and function in beta-cells.
Methods: We first implemented our previous protocol to FACS purify alpha-, beta-, and delta-cells by adding CD81 as a positive marker for alpha-cells.
Tryptophan metabolism promotes immune evasion in human pancreatic β cells.
EBioMedicine
September 2023
Article Synopsis
- The study investigates how pancreatic β cells can resist immune attacks in type 1 diabetes by lowering HLA class I expression and increasing immune inhibitors like PD-L1.
- Tryptophan (TRP) was found to induce PD-L1 through the AKT signaling pathway, which helps β cells evade immune detection while simultaneously reducing the expression of other immune activators like HLA-I and CXCL10.
- Overall, TRP could promote immune tolerance in β cells, making it a potential therapeutic avenue for managing type 1 diabetes by enhancing immune evasion mechanisms.
Article Synopsis
- * A study using flow cytometry found that alpha and delta cells exposed to IFNγ, a significant cytokine in T1D, show a similar inflammatory response as beta cells, including increased expression of key inflammation-related genes.
- * Researchers discovered that the sensitivity to IFNγ among beta cells varies based on their location within the islet rather than being due to distinct cell types, indicating a gradual spread of the cytokine and enhancing our understanding of the inflammatory dynamics in T1D.
Horton disease is difficult to diagnose in the elderly, due to the non-specificity of clinical signs. When evoked in the case of recent headaches, laboratory tests must be carried out to look for signs of inflammation.
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