Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?

Background: Animal models suggest that paternal alcohol consumption may influence offspring traits, yet few human studies exist.

Methods: Data from population-based studies of fetal alcohol spectrum disorders (FASD) among first-grade students provided case-control data to explore traits of fathers of children with: FASD, alcohol exposure, and unexposed controls.

Results: Most males in this population drank, but more fathers of children with FASD drank during pregnancy ( = 73.

Differentiation of Mesenchymal Stromal/Stem Cells from Induced Pluripotent Stem Cells.

Mesenchymal stromal/stem cells (MSCs) possess unique immunomodulatory and regenerative properties, making them ideal candidates for addressing a variety of disorders. With an increasing number of clinical trials, reliable sources are needed to obtain sufficient cell numbers and to circumvent inherent limitations associated with primary cells. Induced pluripotent stem cells (iPSCs) can be differentiated into various somatic cell types and are able to proliferate indefinitely in culture.

Association of opioid and benzodiazepine coprescribing with adverse events among older adults with cancer.

Background: Many older adults with cancer are coprescribed opioids/benzodiazepines; evidence on harms is lacking.

Methods: Using SEER-Medicare (2012-2019), we identified patients with breast, colorectal, or lung cancer. Cox proportional hazards models estimated the adjusted hazard ratios (HRs) of coprescribing (measured from claims, at the day level) with the immediate risk of overdose, fall/fracture, and all-cause hospitalization.