Differences between men who have sex with men that use drugs and engage in chemsex and those who do not engage in chemsex in the French ANRS-PREVENIR cohort: the need to rethink harm reduction services.

Background: An increasing number of studies are exploring the profiles of men who have sex with men (MSM) in the context of the sexualized use of drugs (chemsex). However, less attention has been paid to MSM who use drugs but do not engage in chemsex. We do not know to what extent the latter are different from the former, or whether they require similar harm reduction services.

Factors influencing the prevalence of early pregnancies in Guinean schools: a cross-sectional survey.

Pregnancy in schools is an obstacle to girls' education in low-income countries. The aim of this study was to examine the factors associated with early pregnancy in Guinean schools. It is a survey conducted from December 2020 to March 2021 among adolescent girls attending secondary schools in Guinea.

Trajectories of Chemsex Engagement Across Time Among PrEP-Using Men Who Have Sex with Men: Results from the French ANRS-Prévenir Cohort.

Objectives: To identify trajectories of chemsex engagement and their evolution across time among men who have sex with men (MSM) and the associated factors.

Methods: Among 2518 PrEP-using MSM in the French ANRS- Prévenir cohort, a group-based trajectory model was used to identify trajectories of chemsex engagement. A multivariable model was then used to estimate time-constant factors associated with trajectory membership, and time-varying factors associated with the shape of each trajectory.

Facilitators and barriers to community-based HIV testing in Guinea: a CFIR-based implementation analysis.

Introduction: In Guinea, where 36% of people living with HIV (PLHIV) are unaware of their serostatus, innovative screening strategies are crucial to achieving the joint United Nations Program on HIV/AIDS' 95-95-95 targets. Community-based HIV testing, as recommended by the World Health Organization, aims to reach at-risk populations by leveraging local resources and actors. Using the Consolidated Framework for Implementation Research (CFIR), this study assessed facilitators and barriers to implementing community-based HIV screening across 10 pilot sites in Guinea, with the goal to optimizing its effectiveness.

Quantification of Neural Progenitor Cells From Zika Virus-Infected Zebrafish Embryos.

Zika virus (ZIKV), an arthropod-borne orthoflavivirus, has emerged as a global health concern due to its ability to cause severe fetal neurological disorders, leading to the congenital Zika syndrome (CZS) in neonates. Vertical transmission during pregnancy can alter neural progenitor cell (NPC) proliferation and differentiation and induce apoptosis, leading to microcephaly and other neurodevelopmental abnormalities. While mammalian models have been used to study the impact of ZIKV on NPC behavior, limitations such as high costs, dedicated time, and ethical constraints have fostered the exploration of alternative systems.