A natural language processing pipeline for identifying pediatric long COVID symptoms and functional impacts in freeform clinical notes: a RECOVER study.

Objective: To develop a natural language processing (NLP) pipeline for unstructured electronic health record (EHR) data to identify symptoms and functional impacts associated with Long COVID in children.

Materials And Methods: We analyzed 48 287 outpatient progress notes from 10 618 pediatric patients from 12 institutions. We evaluated notes obtained 28 to 179 days after a COVID-19 diagnosis or positive test.

Occupational Therapy's Role in Schools: A Survey of Occupational Therapy Practitioners.

Importance: Limited evidence exists surrounding the diverse, multifaceted nature of responsibilities and challenges among school-based occupational therapy practitioners (SBOTPs).

Objective: To describe a service delivery model, feedback provision, intervention approaches, roles and responsibilities, and factors contributing to intervention decisions for SBOTPs.

Design: A descriptive electronic survey design with closed- and open-ended questions for January-March 2024.

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function.

Hemoglobinopathies affect approximately 7% of the global population and are associated with an increased risk of autoimmune disorders, though the underlying mechanisms remain unclear. Hemoglobin is traditionally recognized for its role in oxygen transport within erythrocytes, but its expression in other cell types has been documented. We have recently discovered hemoglobin alpha a1 (Hbα-a1 mRNA and Hbα protein) in T-lymphocytes and previously reported that its expression was sensitive to mitochondrial redox perturbations.

Beta adrenergic signaling as a therapeutic target for autoimmunity.

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS) characterized by an autoimmune response where both T-lymphocytes and proinflammatory interleukin 17A (IL-17A) are implicated in the pathogenesis of the disease. We recently identified a molecular mechanism involving beta-adrenergic 1 and 2 receptors (β1/2) in the polarization of T17 lymphocytes. Pharmacological and genetic inhibition of these receptors in combination, but not separately, impaired the ability of T-lymphocytes to produce IL-17A and instead promoted the differentiation of protective T cells that secrete anti-inflammatory interleukin-10 (IL-10).

Population-level phylogenomic analysis yields insights into species cohesion and population substructure of Lobelia section Lobelia (Campanulaceae).

How close relatives maintain species boundaries in sympatry remains a critical question in biodiversity research. Here we introduce Lobelia sect. Lobelia (Campanulaceae) as a useful clade for investigating such questions.