Open surgical management of ureteric strictures: A retrospective study.

Ureteral strictures may arise from long standing nephro/urolithiasis, radiation, use of lasers for treatment of stones, trauma, ischemia, and iatrogenic injury. Therefore, it is of interest to assess the long-term results of ureteral reconstruction using different techniques. Hence, all benign ureteral strictures that more than 2 cm at the level of the pelvi-ureteric junction, upper or mid-ureter, or loss of long length of ureter not suitable for Boar's flap or ureteric reconstruction at a tertiary hospital were included in this study.

Single-cell transcriptomics unveils skin cell specific antifungal immune responses and IL-1Ra- IL-1R immune evasion strategies of emerging fungal pathogen Candida auris.

Candida auris is an emerging multidrug-resistant fungal pathogen that preferentially colonizes and persists in skin tissue, yet the host immune factors that regulate the skin colonization of C. auris in vivo are unknown. In this study, we employed unbiased single-cell transcriptomics of murine skin infected with C.

Cell aggregation mediated by deletion in modulates fungal colonization and host immune responses in the skin.

is an emerging multi-drug-resistant fungal pathogen that colonizes the skin and causes invasive infections in hospitalized patients. Multi-cellular aggregative phenotype is widely reported in the isolates, but its role in skin colonization and host immune response is not yet known. In this study, we generated aggregative phenotype by deleting the gene in and determined the fungal colonization and host immune response using an intradermal mouse model of skin infection.

Single-Cell Transcriptomics Unveils Skin Cell Specific Antifungal Immune Responses and IL-1Ra- IL-1R Immune Evasion Strategies of Emerging Fungal Pathogen .

is an emerging multidrug-resistant fungal pathogen that preferentially colonizes and persists in skin tissue, yet the host immune factors that regulate the skin colonization of are unknown. In this study, we employed unbiased single-cell transcriptomics of murine skin infected with to understand the cell type-specific immune response to skin infection results in the accumulation of immune cells such as neutrophils, inflammatory monocytes, macrophages, dendritic cells, T cells, and NK cells at the site of infection. We identified fibroblasts as a major non-immune cell accumulated in the infected skin tissue.