Novel Benzimidazole-Thiazolidine-2,4-dione Hybrid Compounds as Promising PPAR-γ Modulators with Antidiabetic Activity: Design, Synthesis, Molecular Docking, and In Vitro Evaluation.

Introduction: Design, synthesis, and molecular docking studies of a novel series of Benzimidazole-Thiazolidine-2,4-dione hybrid compounds as PPAR-γ modulators for antidiabetic activity. Thiazolidinediones function as agonists of PPAR-γ, influencing the expression of numerous genes involved in the regulation of glucose, lipid, and protein metabolism. They improve insulin sensitivity by promoting glucose uptake in adipose tissue and skeletal muscle, and by reducing hepatic gluconeogenesis.

Geriatric assessment for predicting outcomes among patients with aortic stenosis undergoing transcatheter aortic valve implantation.

Background: There is scarce data about comparisons between geriatric assessment tools in patients with aortic stenosis (AS). We aimed to describe the geriatric profile of patients with AS undergoing transcatheter aortic valve implantation (TAVI) and to analyze the ability of different tools for predicting clinical outcomes in this context.

Methods: This was a single center retrospective registry including patients with AS undergoing TAVI and surviving to hospital discharge.