Outcomes of ventriculoperitoneal shunt surgery for hydrocephalus in children in low- and middle-income countries: a systematic review.

Objective: Improving outcomes for pediatric patients with hydrocephalus in low- and middle-income countries (LMICs) requires research on ventriculoperitoneal shunt (VPS) complications and outcomes that may be comparable to studies conducted in high-income countries (HICs). The authors aimed to address this gap by conducting a systematic review to analyze VPS complications and outcomes among pediatric patients in LMICs.

Methods: This review adhered to PRISMA guidelines and the Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) quality assessment.

Point-of-Care Urine Metabolomics Test to Diagnose Colorectal Cancers in Low- and Middle-Income Countries: A Pilot Controlled Trial in Southwestern Nigeria.

Purpose: To test the feasibility of a point-of-care (POC) real-time urine metabolomics test, evaluate its validity in diagnosing colorectal cancer (CRC) among at-risk patients, and assess the willingness of patients in Southwestern Nigeria to use and pay for the test.

Methods: This was a pilot-controlled trial carried out among 72 patients (34 cases and 38 controls) in southwestern Nigeria. The cases were those with histopathological diagnosis of CRC while controls were at-risk adults.

Reappraisal of adverse obstetric outcomes independently associated with contemporary fertility treatment practices: a US prospective cohort study.

Background: Obstetric complications linked to assisted reproductive technology could be confounded by underlying parental factors and were often derived from databases not designed to study these complications. With evolving assisted reproductive technology practices, it is unclear to what extent contemporary assisted reproductive technology independently contributes to obstetric risks.

Objective: We aimed to prospectively evaluate obstetric risks associated with contemporary fertility practices, adjusting for parental and assisted reproductive technology parameters.

Beyond the samples: Nigerian research staff perspectives on a multicentre neonatal sepsis study's impact.

Drawing on experiences of Nigerian healthcare staff in a multi-centre international study, we describe insights into capacity strengthening, patients’ engagement, and discuss long-term challenges in sustaining outcomes after project funding ends.